Dendritic Cells Protect Germinal Center B Notch Ligands Expressed by Follicular

Cells from Apoptosis Dendritic Cells Protect Germinal Center B Notch Ligands Expressed by Follicular

The role of CD8+ CD40L+ T cells in the formation of germinal centers in rheumatoid synovitis.

In rheumatoid synovitis, lymphocytes can be arranged in follicular structures resembling secondary lymphoid follicles. To understand the organizing principles of this ectopic lymphoid tissue, the cellular components contributing to synovial follicles were examined. In 9 of 24 synovial tissue biopsies, lymphoid aggregates were found consisting of CD4+ T cells and CD20+ B cells. In four of the ni...

Wnt5a Is Secreted by Follicular Dendritic Cells To Protect Germinal Center B Cells via Wnt/Ca/NFAT/NF-kB–B Cell Lymphoma 6 Signaling

CD137 is expressed by follicular dendritic cells and costimulates B lymphocyte activation in germinal centers.

CD137, a member of the TNF receptor family, and its ligand are expressed on T lymphocytes and antigen-presenting cells (APC), respectively. During interaction with APC, T lymphocytes receive a potent, costimulatory signal through CD137. Reverse signaling has been demonstrated for the CD137 ligand, which causes activation in monocytes. Here we show that B lymphocytes also receive costimulatory s...

Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses

Fibroblast-like cells of secondary lymphoid organs (SLO) are important for tissue architecture. In addition, they regulate lymphocyte compartmentalization through the secretion of chemokines, and participate in the orchestration of appropriate cell-cell interactions required for adaptive immunity. Here, we provide data demonstrating the functional importance of SLO fibroblasts during Notch-medi...